Paraplatin - Paraplatin Information

Generic Name: Carboplatin

Paraplatin is a platinum coordination complex. Cisplatin causes cross linking of DNA; favoured site being N7 of guanine residue. Paraplatin can also react with-SH groups in proteins and has radiomimetic property. Paraplatin is bound to plasma pro­teins, enters, tissues & is slowly excreted unchanged in urine. Paraplatin is very effective in metastatic testicular & ovarian carcinoma. Paraplatin has found use in some other solid tumours as well.

Indications of Paraplatin

• Metastatic testicular and ovarian carcinoma,
• advanced bladder,
• head & neck cancer.

Dosage: Admn by slow infusion 10-60 mg or as required.

Contra Indications: Pregnancy, lactation, hypersensitivity, renal impairment.

Special Precautions of Paraplatin drug

• Maintain good hydration.
• Shock like state sometimes occurs during i.v infusion.
• Monitor haematological,
• neurological status & renal functions.
• Hypomagnesaemia.
• Hypocalcaemia.
• Hyperuricaemia.

Paediatrics -- Not usually prescribed. The risk of hearing loss is increased.

Pregnancy -- Not usually prescribed.

Lactation -- Not advised.

Elderly -- Reduced dose may be necessary.

Side effects of Paraplatin

• Nausea,
• vomiting,
• Tinnitus,
• deafness,
• neuropathy,
• nephrotoxicity,
• electrolyte imbalance.

Drug Interaction of Paraplatin

• Potentiates neurotoxicity with aminoglycosides.
• Ideal combination with other cytotoxic drugs.
• Synergistic with 5-fluorouracil and etoposide.

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