Lomustine

Lomustine is highly lipid soluble alkylating agent with a wide range of anti­tumour activity. They cross blood brain barrier and are effective in meningeal leukemias. & brain tumours.

Indications: Meningeal leukemias, brain tumours, Hodgkin's disease.

Dosage of Lomustine

100-130 mg/sqm. body surface area single oral dose every 6 wks.

Contra indications with Lomustine

• Pregnancy,
• lactation
• Hyper­sensitivity.

Special Precautions of Lomustine

• Renal impairment.
• C.N.S disturbances.
• Monjtor blood counts.

Paediatrics: -- Not recommended in infants. Pregnancy: Safey not established.

Lactation -- Safety not established.

Elderly --- Use with caution.

Side-effects of Lomustine

• Nausea,
• vomiting,
• seizures.
• Bone marrow depression is delayed for 6 wks.
• Visceral fibrosis and renal damage.

Drug Interactions of Lomustine

Theophylline causes leucopenia and thrombocytopenia.

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