Fludarabine

Fludarabine is a cytotoxic chemotherapeutic agent.

Indications of Fludarabine phosphate

Treatment of patients with B-cell chronic lymphocytic leukaemia (Cll) with sufficient bone marrow reserve and who have not responded to or whose disease has progressed during or after treat­ment with at least one alkylating agent containing regimen.

Dosage of Fludarabine

Adults: 25mg/m' body surface given daily for 5 consecutive days in every 28 days by IV route.

Contraindicatlons of Fludarabine

Hypersensitivity to this drug or its components. Renally impaired patients (creatinine clearance < 30ml/minute, and patients with decompensated hemolytic anaemia. Children.

Special Precautions with Fludarabine

• When use at high doses fludarabine is associated with blindness, coma and death.
• Preexisting skin cancer.

Side effects of Fludarabine

• Myelo-suppression (neutropenia, thrombocytopenia and anaemia),
• fever, chills, and infection.
• Oedema,
• malaise,
• fatigue,
• anorexia,
• nausea,
• vomiting, and
• weakness.

Drug Interactions of Fludarabine

1. Pentostatin (deoxycoformycin): use of fludarabine in combination with pentostatin is not recommended because of a very high incidence of fatal pulmonary toxicity.
2. Adenosine uptake inhibitors: The therapeutic efficacy of fludarabine may be reduced by dipyridamole and other adenosine uptake inhibitors.

Cancer Tip Fruit and vegetable consumption may not significantly reduce breast cancer risk, but fruits and vegetables contain phytochemicals and antioxidants that may be protective against other cancers and heart disease. A minimum of five servings per day is recommended.

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