Finasteride propecia

Finasteride, a synthetic 4 azasteroid compound, is a competitive and specific inhibitor of 5 alpha-reductase, an intracellular enzyme that converts testosteronoe into DHT. The bioavailabiiity is about 80% and most absorption occurs within 2 hours.

Indications: Treatment of symptomatic Benign prostatic hyperplasia.

Dosage: 5 mg once daily.

Contraindications: Hypersensitivity, pregnancy.

Special Precautions of Finasteride

Caution should be used in patients with liver function abnormalities, as finasteride is metabolized extensively in the liver.

Paediatrics -- Should not be used.

Pregnancy -- Should not be used.

Lactation -- Use with caution.

Elderly -- Safe.

Side Effects of Finasteride

• Decreased libido,
• gynecomastia,
• impotence and
• reduced volume of ejaculate.

Drug Interactions of Finasteride

May increase clearance of theophylline by 7% and decrease its half life by 10% after IV aminophylline administration.

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