ESTROGENS

Estrogens are palliative; produce gratifying relief in primary as well as metastatic carcinoma prostate. Estrogens is an androgen dependent tumour and estrogens act by suppressing androgen production (through pituitary).

In addition, Estrogens may be antagonizing androgen action in the tumour. Stilbestrol diphosphate is prefered as it is concen­trated in the prostate. Estrogens are also palliative in certain cases of carcinoma breast in late post­menopausal women. Tumours having estrogen receptor 'generally respond, but therapy is reserved for in operable or metastatic cases.

Indications of Estrogens

Palliative treatment of selected cases of disseminated mammary or prostatic carcinoma.

Dosage of Estrogens

Initial treatment with high dosage parenteral therapy. Maint: 1-2 tabs. thrice daily.

Inj. : Initial treatment: 500 mg i.v. daily for 5-10 days, then 250 mg dally for 10-20 days.

Drug Interaction of Estrogens

• Enhance toxic effects of imipramine, reduces effect of anticoaguiants and hypoglycaemic agents.
• Rifampicin, barbiturates and phenytoin increase rate of metabolism.
• Enhance activity of phenytoin.

Cancer Tip Remember you are receiving drugs (chemo-therapy) already. Alcohol and other drugs mayinterfere with the treatment(s) you are receiving.Your kidneys and liver are already working extrahard to deal with chemotherapy. Don’t over-stress them with more drugs.

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Health Tip Electroencephalography (EEG) is a painless procedure used to diagnose abnormal electrical activity in the brain. Electrodes are attached to the scalp and recordings of the brain’s activity are made.

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