Dacarbazine

Indications: Metastatic malignant melanoma. Hodgkin's disease. Soft tissue sarcomas.

Dosage of Dacarbazine

Malignant melanoma: 2-4.5 mg/kg/day for 10 days.

Hodgkin's disease: 150 mg/sq m/day for 5 days.

Treatment may be repeated after 4 weeks.

Contraindlcatlons of Dacarbazine

• Pregnancy,
• lactation,
• marrow suppression,
• hypersensitivity.

Special Precautions of Dacarbazine of drug

• Hematological monitoring periodically warranted.
• Restrict food intake 4-6 hours prior to therapy,
• Caution in handling-irritant to skin & tissues.
• Renal & hepatic impairment.

Paediatrics -- Reduced dose necessary.

Pregnancy -- Contraindicated.

Lactation -- Contraindicated.

Elderly -- Use with caution.

Side effects of Dacarbazine

• Bone marrow suppression,
• hepaitc impairment,
• flu-like syndrome,
• facial flushing, rash,
• CNS disturbances,
• blurred vision,
• paresthesia,
• anorexia, nausea,
• vomiting,
• alopecia,
• Budd-chiari syndrome.

Drug Interactions of Dacarbazine

Dacarbazfne may impair immunological response to live vaccine with development of a generalised vaccinia.

It forms a precipitate with hydrocortisone succinate.

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