Cisplatin - Cisplatin Side Effects

Cisplatin is a platinum coordination complex. Cisplatin causes cross linking of DNA; favoured site being N7 of guanine residue. Cisplatin can also react with-SH groups in proteins and has radiomimetic property. Cisplatin is bound to plasma pro­teins, enters, tissues & is slowly excreted unchanged in urine. Cisplatin is very effective in metastatic testicular & ovarian carcinoma. Cisplatin has found use in some other solid tumours as well.

Indications of Cisplatin

• Metastatic testicular and ovarian carcinoma,
• advanced bladder,
• head & neck cancer.

Dosage: Admn by slow infusion 10-60 mg or as required.

Contra Indications: Pregnancy, lactation, hyper­sensitivity, renal impairment.

Special Precautions of Cisplatin drug

• Maintain good hydration.
• Shock like state sometimes occurs during i.v infusion.
• Monitor haematological,
• neurological status & renal functions.
• Hypomagnesaemia.
• Hypocalcaemia.
• Hyperuricaemia.

Paediatrics -- Not usually prescribed. The risk of hearing loss is increased.

Pregnancy -- Not usually prescribed.

Lactation -- Not advised.

Elderly -- Reduced dose may be necessary.

Side effects of Cisplatin

• Nausea,
• vomiting,
• Tinnitus,
• deafness,
• neuropathy,
• nephrotoxicity,
• electrolyte imbalance.

Drug Interaction of Cisplatin

• Potentiates neurotoxicity with aminoglycosides.
• Ideal combination with other cytotoxic drugs.
• Synergistic with 5-fluorouracil and etoposide.

Cancer Tip In order to receive the best possible benefit from your cancer therapy, it is important to follow your treatment as your doctor has prescribed. Even if you're not able to visit your regular treatment facility, chances are good that you can still maintain your schedule; many other doctors, nurses, and healthcare providers are able to safely administer your treatment.

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