BLEOMYCIN

Bleomycin is a mixture of closely related antitumour antibiotics. Bleomycin chelates copper or iron, intercalates between DNA strands-causes chain scission and inhibits repair.

Indications of Bleomycin

• Testicular tumour,
• squamous cell carcinoma of skin, head and neck,
• genitourinary tract and oesophagus,
• Hodgkin's lymphoma.
• Malignancy 0 lungs and cervix.

Dosage of Bleomycin

30 mg twice weekly in average cases otherwise dose can be varied between 15 mg daily to 15 mg weekly. Total dose: 300-400 mg. Contra-Indications: Do not mix glutathione with bleomycin. Pre-existing lung diseases.

Special Precautions with Bleomycin

Paediatrics -- Safety not established.

Pregnancy -- Should not be used.

Lactation -- Should not be used.

Elderly -- Dose adjustment is necessary.

Side effects of Bleomycin

• Mucocutaneous toxicity,
• pulmonary fibrosis.
• Dermatitis.
• Nephrotoxicity.
• Hepatic toxicity.

Drug Interactions of Bleomycin

Cisplatin enhances the pulmonary toxicity, nephrotoxic agents increases the nephrotoxicity.

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