L-ASPARAGINASE

Observing the qualitative difference observed between normal cells and those from childhood lymphoblastic leukemia - the leukemia cells are deficient in L-aspargine synthetase and depend on the supply of L-asparagine from the medium. The enzyme L-asparaginase (from E. coli) degrades L-asparagine to L-aspartic acid; depriving leukemic cells of an essential metabolite - may cause cell death.

Indications: Acute leukaemia. Malignant lymphoma..

Dosage of L-Asparaginase

50-200 k.u/kg body wt. daily or every alternate day by i.v. infusion.

Contra-Indications: Hypersensitivity.

Special Precautions of L-Asparaginase

Anaphylaxis can occur, allergic reaction (being a foreign protein).

Paediatrics -- Safe.

Pregnancy -- Should not be used.

Lactation -- Should not be used.

Elderly -- Use with caution.

Side effects of L-Asparaginase

• Liver damage,
• pancreatitis and C.N.S symptoms (due to defective protein synthesis)

Drug Interactions of L-Asparaginase

Vincristine and prednisolone increases the toxicity, diminishes or abolishes the effect of methotrexate on malignant cells.

Cancer Tip In order to receive the best possible benefit from your cancer therapy, it is important to follow your treatment as your doctor has prescribed. Even if you're not able to visit your regular treatment facility, chances are good that you can still maintain your schedule; many other doctors, nurses, and healthcare providers are able to safely administer your treatment.

Become a regular visitor at our " Cancer Care Blog " - Here are the latest blog entries: Treatment for migraine Cancer Fighting Crucifers Is Common Sense or Research Needed to Cure Cancer? Surgical castration or bilateral orchidectomy Things Women Can Do to Prevent Cancer Things Men Can Do to Prevent Cancer

Health Tip Drinking plenty of fluids will help to ease a sore throat and clear congestion of the nasal passages. Lying propped up on several pillows will help to control nighttime coughing.

Home . Mesothelioma . Mesothelioma Fact . Mesothelioma Asbestos . Mesothelioma Symptom . Mesothelioma Treatment . Mesothelioma Diagnosis . Mesothelioma Causes . Malignant Mesothelioma . Mesothelioma Stage . Pleural Mesothelioma . Mesothelioma Update . Asbestos . Asbestosis . Chemotherapy